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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Chen Wang

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Open access Sep 2026

Affinity and costimulatory architecture-associated toxicity in mesothelin-targeted TCR-mimetic CAR-T cells

Modifying either the affinity-related properties or the 80BB-based architecture preserved efficacy while reducing toxicity, providing potential design considerations for affinity selection and co-stimulator design in the mesothelin-targeted TCR-mimetic CAR-T platform.

Wei Du, Si-Qi Li, Shao-Mei Gan et al. · 0 citations
Jul 2026

[Development of a rapid chimeric antigen receptor (CAR)-T production process and assessment of critical quality attributes].

Results indicate that the 24 h rapid production strategy is feasible and provides a promising technical approach to shorten patient waiting time, reduce production costs, and generate functionally improved CAR-T cell products for clinical translation.

Siqi Li, Wen-Bin Yu, Chen Wang et al. · 0 citations
Jul 2026

Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma.

This work integrated single-cell profiling and spatial transcriptomics of glioma-associated microglia in the GL261 model to identify distinct microglial states that aligned with tumor architecture and highlighted microglial state transitions as a stage-specific layer of immune regulation in glioma that shapes T cell fa...

Jia-Wen Qian, Chen Wang, Yi Zhang et al. · 0 citations

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