Chen-Sheng Huang

RpS19a depletion alters the hematopoietic translatome to drive tissue overgrowth

Summary Despite ribosomal protein loss correlating with increased tumor predisposition, direct mechanisms for the counterintuitive oncogenic effect of ribosomal protein depletion have not been reported. We used genetic models to investigate ribosomal protein S19a (RpS19a) depletion in the Drosophila blood organ, the ly...