Author

Chen-Na Liu

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Review Open access Aug 2026

Modulation of Inflammation-Driven Hepatocarcinogenesis: The Hepatic Immune Microenvironment, Gut–Liver Axis, and Neuroregulation

A deeper understanding of fundamental pathological mechanisms provides a conceptual framework for elucidating the initiation and progression of HCC and offers a theoretical basis for the future development of preventive and targeted therapeutic strategies, although the translation of these mechanistic insights into cli...

Wei-Chen Yu, Kai Yin, Chen-Na Liu et al. · Journal of Hepatocellular Ca... · 0 citations

Open access Jul 2026

AARS1-catalyzed H4K12 lactylation promotes HCC resistance to targeted therapy by activating RAPGEF3-RAP1 signaling.

A novel metabolic-epigenetic mechanism whereby lactate modulates hepatocellular carcinoma sensitivity to targeted therapies through histone lactylation is delineated and suggests AARS1-H4K12la-RAPGEF3 axis may serve as an interventional target to overcome targeted drug resistance, offering a promising strategy to enhan...

Tanlun Zeng, Wanwan Zhu, Guanqun Sun et al. · Cell Death and Disease · 1 citation