Author

Chen Chen

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Open access Jan 2026

Identification of PD‐1‐Related Genes as Prognostic Biomarkers in Lung Adenocarcinoma

Background The PD‐1/PD‐L1 axis plays a critical role in suppressing T‐cell activation and facilitating immune evasion in lung adenocarcinoma (LUAD). This study focused on PD‐1‐related genes to develop a robust prognostic prediction model for LUAD. Methods Immune scores were calculated using the ESTIMATE algorithm, and...

Bin Jia, Ting Gong, Chen Chen et al. · Human Mutation · 0 citations

Open access Jul 2026

NSUN2-mediated m5C modification of E2F1 promotes lung adenocarcinoma progression via the RAD54L signaling axis.

This work identifies a hierarchical signaling axis driven by the RNA methyltransferase NSUN2 that fuels LUAD progression and establishes the NSUN2-E2F1-RAD54L axis as a critical driver of LUAD and a promising target for therapeutic intervention.

Yue Li, Chen Chen, Hailin Liu et al. · Respiratory Research · 0 citations