Open access
Oct 2026
The Alzheimer’s disease-associated rs28834970 variant in PTK2B impairs electrical activity and regulates Tau phosphorylation and APP processing in human neuronal cultures
Background Genome-wide association studies have identified the PTK2B gene, which encodes Proline-rich tyrosine kinase 2 (PYK2), as a genetic risk factor for Alzheimer’s disease (AD). However, its role in AD aetiology remains to be understood, as a complex contribution to amyloid β (Aβ) toxicity, tauopathy and neuronal...
Nina Lannette-Weimann, M. Huyvaert, Floriane Limoge et al.
· bioRxiv · 0 citations