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Author

Charles R. Mackay

2 papers indexed here

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Aug 2026

Hydroxyethyl starch serves as a superior vehicle for colon-targeted delivery of indole-3-acetic acid to enhance therapeutic efficacy against colitis.

Indole-3-acetic acid (IAA), a crucial tryptophan-derived metabolite, exerts anti-inflammatory and immunomodulatory effects primarily through activation of aryl hydrocarbon receptor (AhR) and modulation of gut immune homeostasis, providing a mechanistic rationale for its use in colitis. Colon-targeted delivery of IAA to...

Lin Tian, Qian Gong, Wen-Shan Yang et al. · 1 citation
Open access Sep 2026

HAMSIAA protects cyclophosphamide induced immunosuppression by modulating gut homeostasis and purine metabolism

Introduction Dietary supplementation with functional starches serves as a promising intervention strategy for immune regulation, yet the immunomodulatory efficacy and underlying mechanisms of newly developed modified starch derivatives remain to be further explored. In this study, a cyclophosphamide (CTX) induced secon...

Di Zhang, Ying-Ying Song, Shi-Hao Guo et al. · 0 citations

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