Hydroxyethyl starch serves as a superior vehicle for colon-targeted delivery of indole-3-acetic acid to enhance therapeutic efficacy against colitis.
Indole-3-acetic acid (IAA), a crucial tryptophan-derived metabolite, exerts anti-inflammatory and immunomodulatory effects primarily through activation of aryl hydrocarbon receptor (AhR) and modulation of gut immune homeostasis, providing a mechanistic rationale for its use in colitis. Colon-targeted delivery of IAA to...