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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Chao Yang

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Review Open access Jul 2026

Integrated Engineering of CAR‐T Cells for Solid Tumours

This review examines the transition from single‐axis engineering to an integrated framework that addresses hurdles in sequence, and delineates how next‐generation CAR‐T cells are designed for precise spatiotemporal activation through logic‐gated and pharmacologically regulatable receptors, while being reinforced by metabolic and epigenetic reprogramming to resist TME‐driven exhaustion.

Chao Yang, Tan Li, Ping He et al. · 0 citations

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