Biomimetic Bilayer Hydrogel for Scar-Minimizing Healing of Deep Second–Degree Burns Through Sequential Macrophage–Fibroblast Intervention
During the inflammatory phase, the persistent macrophage-mediated inflammatory response, followed by excessive fibroblast activation in the proliferative phase, impairs the repair of deep partial-thickness burn wounds and contributes to scar formation. Hence, precise spatiotemporal regulation of both macrophages and fi...