Author

Chao Song

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Open access Oct 2026

SLFN11 suppresses PD-L1 through CDK4-mediated BRD4 phosphorylation and ubiquitination by USP10/TRIM21

Pancreatic ductal adenocarcinoma (PDAC) exhibits a dismal prognosis driven by the interplay between dysregulated cell cycle progression in malignant cells and an immunosuppressive tumor microenvironment (TME). Proliferative PDAC subtypes are characterized by heightened immunosuppressive signatures and diminished cy...

Mao-Zhen Peng, Wei Wang, Chao Song et al. · Cell Death & Disease · 0 citations

Sep 2026

DDR1 sustains ferroptosis resistance in pancreatic ductal adenocarcinoma via SLC40A1-mediated iron homeostasis.

Findings identify DDR1 as a key regulator of iron metabolism and ferroptosis in PDAC, suggesting that dual targeting of DDR1 and ferroptosis represents a promising therapeutic strategy.

Chao Song, Lu-Ting Zhang, Sheng Xu et al. · Oncogene · 0 citations

Jul 2026

ARID1A Stimulates Notch-TLL1 Signaling to Induce Cancer-Associated Fibroblast Activation and Intrahepatic Cholangiocarcinoma Development.

It is demonstrated that ARID1A, a core component of the SWI/SNF protein complex, is upregulated in ICC and plays an oncogenic role and acarbose is revealed as a potential precision therapy for ARID1A-high ICC patients.

Sheng Xu, Jing-Yi Huang, Kang Wang et al. · Cancer Research · 0 citations