Review
Open access
Aug 2026
Synovial immune control failure in osteoarthritis: from maintenance of tissue homeostasis to inflammatory niche formation
Osteoarthritis (OA) is a whole-joint disease involving cartilage, synovium, subchondral bone, and neurovascular structures. Synovitis, damage-associated molecular patterns, and interactions between macrophages and fibroblast-like synoviocytes have been widely studied. However, a tissue-level explanation is still lackin...
Kang-Yi Hu, Yong-Jia Song, Jia-Xing Pan et al.
· Frontiers in Immunology · 0 citations