Aug 2026
A dendritic cell autophagy-neutrophil axis limits intratumoral STING immunotherapy.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway promotes tumor immunogenicity, but intratumoral STING agonists, despite strong preclinical efficacy, have shown limited clinical efficacy. The mechanisms restricting therapeutic STING activation remain unclear. In mice, intratumoral deliv...
Adriana Loverre, Bakhos Jneid, F. Delisle et al.
· Science immunology · 0 citations