Discovery of Substituted N-Arylindole Diamides as Insecticidal Candidates Targeting Ryanodine Receptor.
Natural products are important sources of bioactive fragments. Based on the scaffold-hopping strategy, 40 novel N-arylindole diamide derivatives with excellent insecticidal activity were synthesized by substituting the pyrazole moiety of chlorantraniliprole (CHL) with a natural indole substructure. Bioassay results dem...