Author

Changna Han

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Open access Jul 2026

A tumor microenvironment-responsive calcium overload nanoplatform inducing PANoptosis for enhanced cancer immunotherapy

The results indicate that calcium overload, FTY720-mediated TRPM7 inhibition, and MnO2-induced redox imbalance can drive PANoptosis, offering a new concept for enhancing cancer immunotherapy.

Aiyang Tong, Yang Zhou, Yang Ding et al. · Materials Today Bio · 0 citations

Jul 2026

PNPT1-induced mitochondrial dysfunction drives osteoclast activation via post-transcriptional Nrf2 suppression and lipid peroxidation signaling.

By inciting mitochondrial damage, provoking ROS buildup, and decoupling the protective autophagy-Nrf2/xCT axis, PNPT1 promotes osteoclastogenesis, thereby introducing a promising immunopharmacological target for restraining pathological bone resorption.

ChengYan Liu, Xinlin Nie, Fangze Xing et al. · International Immunopharmaco... · 0 citations