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Carriers of rare protein-truncating variants in schizophrenia risk genes were identified in 30,813 patients of a US healthcare system and an X-linked pattern of inheritance between the PTV and severe mental illness was found.
NO-assisted LNPs are established as a unique platform for potent mRNA delivery, which provides a new paradigm for overcoming endosomal barriers and improving the efficacy of mRNA vaccines.
This work designed, synthesized, and tested a series of ionizable lipids and formulated them into CNS-accessing lipid nanoparticles (CA LNPs) to deliver mRNA, and the lead candidate, CA2d LNP, demonstrated efficient mRNA delivery across the blood-brain barrier following intravenous injection.
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