HNF-4α regulates hepatoma cell growth and apoptosis through the IGFBP-2/Notch1 signaling pathway
Abstract: Background: Hepatocyte nuclear factor 4α (HNF-4α) is a liver-enriched transcription factor that is downregulated in hepatocellular carcinoma (HCC). However, the molecular mechanisms by which it regulates the malignant phenotype of HCC cells remain unclear. Objectives: To investigate whether HNF-4α affects HCC...