Background: Abnormal heart rate is a common early manifestation of sepsis, but the association of the dynamic changes with clinical outcomes remains unclear. This study aimed to investigate the relationship between dynamic heart rate trajectories and 28-day mortality as well as acute kidney injury (AKI) in patients wit...
Yang Yang, Hang-Xiang Du, Zhen-Liang Wen et al.· Journal of Clinical Medicine· 0 citations
Sepsis, a life-threatening syndrome driven by dysregulated host response to infection, is critically exacerbated by the uncontrolled formation of neutrophil extracellular traps (NETs), which amplify inflammation, promote microthrombosis, and precipitate multiple organ dysfunction. However, current therapeutic approache...
Nan Wang, Yu-Qin Jin, Jian Song et al.· Science Advances· 0 citations
Deoxyguanosine triphosphatases (dGTPases) are nucleotide-depleting enzymes known to play a role in antiviral defense. While their enzymatic mechanism is established, the structural and functional diversity of dGTPases remains poorly understood. Here, we report a systematic analysis of dGTPase homologs across bacteria,...
Miao Shi, Peipei Li, Quanjin Li et al.· Nature Communications· 0 citations
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