Author

Changshuai Zhou

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Open access Sep 2026

Matrine Suppresses Lung Cancer Progression via Dual Inhibition of CHEK1‐Mediated DNA Damage Repair and PI3K/AKT Survival Signaling

Lung cancer remains a leading cause of cancer‐related mortality worldwide, necessitating the development of novel therapeutic strategies. Matrine, a natural alkaloid derived from Sophora flavescens, has demonstrated broad antitumor properties, yet its underlying mechanisms, particularly concerning DNA damage response,...

Jiang-Hao Yu, Si-Yang Chen, Ting-Ting Hou et al. · Thoracic Cancer · 0 citations

Open access Jul 2026

Upregulation of macrophage UPP1 promotes lung adenocarcinoma metastasis through an mtROS-cGAS-NLRP3 inflammasome axis.

A macrophage-specific immunometabolic circuit in which UPP1-driven mitochondrial stress activates the mtROS-cGAS-NLRP3 axis, promoting IL-1β-dependent macrophage-tumor crosstalk and metastatic progression is identified.

Mingtao Feng, Chao Gao, Yue-fei Yang et al. · Cell Death Discovery · 0 citations