Author

Chang-Lin Tian

2 papers indexed here

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Open access Sep 2026

Sortase-mediated generation of various macrocyclic peptide scaffolds from low-reactivity electrophilic substrates

Macrocyclic peptides possess numerous advantages, including enhanced tissue penetration, low immunogenicity, good resistance to protease degradation, and high targeting specificity, making them increasingly attractive for drug development. Genetically encoded cyclic peptide libraries enable rapid and convenient de novo...

Zhe-Min Xia, Hui-Min Wei, Jun-Hao Xue et al. · Chemical Science · 0 citations

Oct 2026

Monofluoromethylphenylalanine: A Sensitive 19F Probe for Protein Conformational Dynamics In Vitro and in Cells

The combination of site-specific incorporation of 19F-labeled unnatural amino acids (UAAs) and 19F nuclear magnetic resonance (NMR) spectroscopy is a powerful strategy for investigating protein structure, dynamics, and interactions. However, commonly used 19F-containing UAAs often suffer from narrow chemical shift di...

Pan Shi, Jun Liang, Xiao-Li Liu et al. · Journal of the American Chem... · 0 citations