A major challenge in auricular reconstruction is the endochondral ossification of engineered cartilage after subcutaneous implantation. To overcome this, we developed a functionally tailored, hybrid hydrogel scaffold that integrates anti‐angiogenic therapy with biomimetic architecture to stabilize the chondrogenic ph...
Bo-Qing Zhang, Yu Liu, Hai-Rui Li et al.· Advanced Functional Material...· 0 citations
Digital light processing (DLP) 3D printing of hydroxyapatite (HA) bioceramics offers a promising strategy for fabricating complex, patient-specific bio-root scaffolds with high resolution and bioactivity. However, achieving adequate mechanical integrity while guiding the formation of a periodontal ligament (PDL)-like e...
Zhuo-Ping Bai, Xingyu Gui, Bo-Qing Zhang et al.· Journal of materials chemist...· 0 citations
Structural facial cartilage regeneration is impeded by limited intrinsic repair and injury-driven inflammatory remodeling, which promote fibrosis, matrix degradation, and phenotypic instability. Here, we report a temporally programmed immuno-chondrogenic hydrogel system that combines mesenchymal stem cells (MSCs) with...
Jing-Ting Huang, Si-Jie Li, Xi-Hao Wang et al.· Journal of materials chemist...· 0 citations
Intracerebral hemorrhage (ICH) remains a highly lethal and disabling subtype of stroke, and the lack of effective disease-modifying therapies largely reflects the complexity of its secondary injury mechanisms: oxidative stress predominates early and fuels neuroinflammation, whereas impaired neurorepair persists into th...
Ruiying Han, Yun-Sen He, Yong-Lin He et al.· ACS Applied Materials and In...· 0 citations
A multifunctional hydrogel dressing was constructed from carboxymethyl chitosan and oxidized dextran as the dynamic network, incorporating CeO2 nanozymes for early anti-inflammatory and antioxidant effects and PLGA microspheres loaded with astragaloside IV for sustained pro-regeneration.
Xi-Hao Wang, Jing-Ting Huang, Chuipin Kong et al.· ACS Applied Materials and In...· 0 citations
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