Chanaphat Thetsana

Heterologous expression reveals a cryptic morphogenetic lanthipeptide durhapeptin from Streptomyces durhamensis

Morphological differentiation in Streptomyces is regulated by extracellular peptide signals, including class III lanthipeptides such as SapB and AmfS. Genome mining of Streptomyces durhamensis identified a previously uncharacterized class III lanthipeptide biosynthetic gene cluster. The precursor peptide and the modify...