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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Chak-Hon Luk

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Open access Oct 2026

ESX-1 remodels the Mycobacterium tuberculosis antigen storage compartment in macrophages

Mycobacterium tuberculosis (Mtb) secretes antigenic proteins that drive protective T cell responses, yet how Mtb intracellular localization affects the trafficking and spatiotemporal distribution of mycobacterial antigens in macrophages remains elusive. Here, we developed a split fluorescent protein reporter to monitor...

Chak-Hon Luk, Tania Auchynnikava, A. Fearns et al. · 0 citations
Open access Jul 2026

The LRRK2 G2019S variant rewires Rab GTPase phosphorylation after lysosomal damage and promotes cell death in human macrophages

It is shown that LRRK2 G2019S has an effect during lysosomal damage through kinase-dependent and kinase-independent mechanisms, and isogenic induced pluripotent stem cells from patients carrying the LRRK2 G2019S variant confirmed that LRRK2 G2019S macrophages are more susceptible to cell death in a kinase-independent m...

Rebecca Morrison, Simeon R. Mihaylov, Chak-Hon Luk et al. · 1 citation

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