Chaithanya P. Vedula

Genetic Medicine Approaches for Tumor Suppressor Loss: Therapeutic Replacement with Self-Amplifying RNA

Deletion or functional inactivation of tumor suppressor genes is a hallmark of human cancers. Unlike hyperactive oncogenes, which produce proteins that are targetable through pharmacologic inhibition, treatments to restore tumor suppressor protein activity are challenging given the loss-of-function nature of tumor supp...