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Ceren Yıldırım

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Open access Sep 2026

PHACTn enables training-free, context-independent inference of nucleotide variant tolerance across the genome

PHACTn (Phylogeny-Aware Computing of Tolerance for nucleotide variants), a training-free, parameter-minimal method that infers nucleotide variant tolerability by traversing the mammalian phylogenetic tree and explicitly modeling the evolutionary independence of observed substitutions and their distance from the query s...

Ceren Yıldırım, Nurdan Kuru, Ogun Adebali · 0 citations
Open access Aug 2026

Exploratory longitudinal analysis of a PIN1-associated gene panel in PBMCs during orbital spaceflight

Analysis of peripheral blood mononuclear cell RNA-sequencing data from three Axiom-3 astronauts provided hypothesis-generating evidence supporting further evaluation of PIN1-associated transcriptional responses in larger astronaut cohorts using protein-level, functional, and cell-type-resolved analyses.

Cihan Taştan, Z. Uzun, Ceren Yıldırım et al. · 0 citations

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