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Author

Cen-Cen Lei

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Oct 2026

Discovery of Novel STING Inhibitors for the Treatment of Severe Acute Pancreatitis

Stimulator of interferon genes (STING) is a promising therapeutic target for severe acute pancreatitis (SAP), but effective small-molecule inhibitors remain limited. Here, structure−activity relationship studies identified compound D4 as a potent STING inhibitor with favorable cellular activity and safety. D4 directl...

Fa-Min Zhang, Xin-Wang Li, Bin Zhu et al. · 0 citations
Aug 2026

Discovery of a novel CDK8 inhibitor as dual suppressor of NF-κB-driven inflammation and promoter of Treg differentiation for psoriasis treatment.

LW-1 represents a promising CDK8 inhibitor with improved drug-like properties and potent anti-psoriatic efficacy, providing a potential therapeutic candidate for the treatment of psoriasis and other inflammatory diseases.

Cen-Cen Lei, Dawei Jin, A-Jun Liu et al. · 0 citations

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