Celia Rodriguez-Casas

μ-Opioid receptors negatively regulate striatal dopamine D1 receptor signaling through heteromerization

Integrating biophysical, computational, in situ, and in vivo approaches with selective heteromer-disrupting transmembrane peptides, this study demonstrates that μ-opioid receptors (MORs) and dopamine D1 receptors (D1Rs) assemble into functional heteromers. Furthermore, real-time in vivo fiber photometry using a genetic...