Open access
Oct 2026
Targeting CD44v6 and PI3K disrupts HGF-driven reprogramming of colorectal cancer stem cells
Therapeutic adaptive responses and secondary resistance represent major obstacles to effective colorectal cancer treatment. These dynamic adaptations arise within a permissive tumor microenvironment that sustains cancer cell survival, epithelial-mesenchymal plasticity and the outgrowth of drug-tolerant clones, ultima...
Kimiya Shams, Francesco Verona, Ornella Roberta Brancato et al.
· Cell Death Discovery · 0 citations