Open access
Aug 2026
FGFR3-driven gene regulatory network analysis reveals a protumoral role for p63 in luminal bladder tumors
Findings support p63 as a protumorigenic regulator in FGFR3-mutated tumors despite their luminal differentiation and provide a detailed FGFR3-driven GRN, offering insights into FGFR3-induced oncogenic dependency and potential strategies to circumvent resistance to FGFR inhibitors.
A. Moreno-Vega, M. Zambrano, Lilia Estrada-Virrueta et al.
· Journal of Clinical Investig... · 0 citations