Author

Carolyn A. Martin

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Open access Jul 2026

SPARC: A Graph-based Optimization Framework for Directional Trajectory Reconstruction Across Ordered Single-Cell Conditions

SPARC is presented, a graph-based optimization framework that quantifies similarity in a shared high-dimensional latent space and reconstruct directional trajectories under biological constraints and is the first to propose a “cross-organ bone-like microenvironment” hypothesis.

Shifeng Wu, W. C. Walker, Carolyn A. Martin et al. · bioRxiv · 0 citations