Caroline C. Rodgers

Neurodegeneration as Convergent Three-Pathway Failure: A Unified Framework for Alzheimer’s and Related Dementias

Alzheimer’s and related dementias are not inevitable consequences of aging. This manuscript proposes that they arise when cumulative stress exceeds the repair capacity of three biological systems critical for maintaining brain health: proteostatic capacity, mitochondrial function, and neuroimmune regulation. In most ca...