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Author

Carolina Filipponi

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#protein folding Open access Oct 2026

Non-electrophilic TRPA1 modulator MNP-021 protects neuronal and glial function from diabetes-associated glucotoxicity and neuroinflammation

In a sustained high-glucose model, MNP-021 reduced the high-glucose-associated increase in cell death, extending its protective effects beyond the acute MGO paradigm, and support further preclinical evaluation of MNP-021 in dicarbonyl-linked neuro-metabolic stress.

Alessandro De Carli, Carolina Filipponi, Beatrice Polini et al. · 0 citations
Review Open access Sep 2026

The Paradox of Tau and RNA-Binding Proteins: How Adaptive Stress Granule Regulation Becomes Pathological with Aging

Reducing biomolecular condensates in stress and disease could provide a general effective therapeutic approach for multiple neurodegenerative diseases, according to specific pathways being pursued for reducing levels of stress granules, aggregated RNA binding proteins and oligomeric Tau.

Benjamin Wolozin, Merci N. Best, Madhav Ellini et al. · 0 citations

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