Neuroinflammation is implicated in Alzheimer’s disease (AD) pathogenesis, yet how changes in TSPO PET signal are associated with tau deposition, and how brain network architecture shapes this relationship remain poorly understood. We conducted a prospective, multimodal neuroimaging study in 56 participants: 35 amyloid-...
M. Öchsner, M. Brendel, N. Franzmeier et al.· Alzheimer's Research & Thera...· 0 citations
Abstract BACKGROUND Tau pathology in Alzheimer's disease (AD) propagates along the brain's connectome, yet the mechanisms by which tau drives neuronal dysfunction remain unclear. We hypothesized that dysfunction primarily emerges in regions close to tau‐harboring epicenters. METHODS One hundred thirty‐one amyloid‐posit...
Lukas Frontzkowski, Sebastian N. Roemer-Cassiano, Johannes S. Gnörich et al.· Alzheimer's & Dementia· 0 citations
Interestingly, subjective cognitive concerns assessed by the Subjective Cognitive Decline Questionnaire were strongly associated with overall subjective symptom burden, supporting the use of brief self-report questionnaires as a pragmatic and scalable first-step stratification approach in community-based dementia detec...
Carolin I. Kurz, Nikola Clara-Sophie Wüsten, Paulina Tegethoff et al.· Scientific Reports· 0 citations
In CSF-confirmed participants, age emerged as the most consistent predictor of plasma biomarker levels, particularly NFL and pTau181, which suggests that plasma biomarkers are influenced primarily by age and genetic background rather than by metabolic factors in this cohort.
Carolin I. Kurz, Marleen Taute, Paulina Tegethoff et al.· Aging Brain· 0 citations
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