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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Carolin Göbel

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Open access Aug 2026

Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma

It is demonstrated that aberrant Sonic Hedgehog (SHH) signaling during embryonic Choroid Plexus (CP) development triggers a dedifferentiation cascade that reverts mature epithelium to a progenitor-like state and identifies that these tumor cells cultivated in vitro are vulnerable to ATR and CDK inhibition.

Levke-Sophie Peter, L. Altendorf, K. Hack et al. · 0 citations

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