Review
Open access
Oct 2026
Targeting Sirtuins in Neurodegenerative and Psychiatric Disorders: From Molecular Mechanisms to Pharmacological Modulation
Neurological and psychiatric disorders share several biological mechanisms, including mitochondrial dysfunction, oxidative stress, neuroinflammation, impaired protein homeostasis, and changes in synaptic plasticity. Sirtuins (SIRT) are nicotinamide adenine dinucleotide (NAD+)-dependent enzymes that regulate cellular me...
A. F. Păduraru, Raluca-Sînziana Zaharia, Iuliana Roată et al.
· Neurology International · 0 citations