A phenotypic screening approach was applied to identify compounds active against S. chrysophrii, and niclosamide, one of the most potent compounds identified, demonstrated a parasiticidal activity more than 11,000-times greater than praziquantel, a reference chemotherapeutic agent commonly used against fish polyopistho...
Ana León, Teresa Pirollo, Elnaz Aledavood et al.· Veterinary parasitology· 0 citations
This review provides a structured overview of biologics and natural products in the ALS clinical pipeline, with particular emphasis on candidates that entered, advanced through, or completed clinical evaluation between 2022 and the end of 2025.
C. Huang, C. Sanchez-Santos, L. Martínez-González et al.· Expert Opinion on Investigat...· 0 citations
This study demonstrates the advantages of integrating AI with FBDD to streamline molecular design, providing a data-driven framework for discovering new Mac1 inhibitors and guiding future antiviral drug development.
Elnaz Aledavood, Sandra Ramos-Inza, Jannis Born et al.· Communications Chemistry· 0 citations
It is found that these inhibitors reduce TDP-43 phosphorylation levels in neuroblastoma cells and FTD patient-derived models, and restores cognitive deficits, conferred neuroprotection in the frontal cortex, and reduced microglial activation in an FTD-TDP mouse model, supporting its therapeutic potential.
Cecilia Sanchez-Santos, Alberto Jiménez-Amor, Loreto Martínez-González et al.· Journal of Medicinal Chemist...· 0 citations
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