Temporal Trends and Predictors of Mortality in Heart Failure with Reduced Ejection Fraction: The Role of Renal Function and Left Ventricular Improvement
The improvement of left ventricular ejection fraction (LVEF) emerged as a protective factor against long-term all-cause mortality in HFrEF, suggesting that clinical management should shift from early pharmacological optimization towards a multidisciplinary approach focused on long-term non-cardiovascular risk.