Author

Carlos M. Telleria

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#protein folding Open access Oct 2026

Nelfinavir Synergizes with Cisplatin and Promotes GSDME-Associated Lytic Cell Death in Platinum-Resistant Ovarian Cancer Cells

Background/Objectives: Platinum resistance limits the efficacy of ovarian cancer treatment and arises through multiple mechanisms, including enhanced DNA repair, activation of stress responses, and increased survival signaling. Nelfinavir (NFV), an HIV protease inhibitor with reported anti-tumor activity, is a candidat...

Benjamin N. Forgie, R. Prakash, Desiree Marno et al. · Pharmaceuticals · 0 citations

Open access Oct 2026

An Evidence-Based Knowledge Graph Framework with Large Language Models and Human-in-the-Loop for Ovarian Cancer Resistance

The reciprocal relationship between large language models (LLMs) and knowledge graphs (KGs) opens new opportunities for knowledge discovery from scientific literature; however, most approaches address only one direction of this interaction. In complex biomedical domains, ensuring reliability, interpretability, and trac...

Horacio Thompson, R. A. Conforti, S. Andújar et al. · Machine Learning and Knowled... · 0 citations