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Author

Carlos Alfonso-Gonzalez

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Sep 2026

Dysregulated Ribonucleoprotein Granules Impair Mitochondrial Function in RBM20-Related Dilated Cardiomyopathy.

BACKGROUND Pathogenic variants in RBM20 cause severe dilated cardiomyopathy. Loss-of-function variants disrupt splicing; neomorphic gain-of-function (GoF) variants also mislocalize RBM20 to cytoplasmic ribonucleoprotein granules and are associated with more aggressive disease. The mechanism by which RBM20 mislocalizati...

Julia Kornienko, Linda H. Müller, A. Nickel et al. · 0 citations
Open access Jul 2026

Regulation of protein abundance in neurons by selective translation of 3′UTR isoforms

3′UTR-mediated translational control is proposed as an evolutionarily conserved mechanism for the maintenance of cell-type-specific proteostasis for the maintenance of cell-type-specific protein synthesis in neurons.

Sakshi Gorey, Hasan Can Ozbulut, Judit Carrasco et al. · 0 citations

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