Carla P. Concepcion-Crisol

A novel CAF population coordinates hyper-suppressive regulatory T cell recruitment and localization in lung cancer

Across many solid tumor types, cancer-associated fibroblasts (CAFs) are abundant and heterogeneous, with distinct subpopulations exerting immunomodulatory functions. Here we identify a novel population of immunomodulatory CAFs (imCAFs) in primary lung adenocarcinoma and pulmonary metastases, characterized by cell adhes...