Abstract Objective: Focusing on the process by which PM2.5 induces NLRP3/Caspase-1 axis activation and drives GSDMD-mediated pyroptosis, this study aimed to construct an integrated framework combining evidence from a PM2.5 animal model, intervention with a pyroptosis inhibitor, and reproducible screening of public tran...
Yi Luo, Cao Wang, Hong-Qiong Ma· Research Square· 0 citations
Exposure to PM2.5 significantly elevated the levels of several testicular proteins, including NLRP3, ASC, cleaved caspase-1, cleaved caspase-1, cleaved caspase-3, GSDMD-N, total caspase-1, and full-length GSDMD, whereas cleaved caspase-3 did not differ significantly.
Yi Luo, Cao Wang, Meng-Xi Tian et al.· PLoS ONE· 0 citations
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