Author

Can Luo

2 papers indexed here

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Open access Sep 2026

A little longer, a lot better: simulation-guided exploration of extended-length single-end barcoded reads for structural variant detection

increasing read length consistently improves SV detection accuracy, with SE1000_stLFR achieving the best performance among the evaluated stLFR configurations and showing competitive performance relative to ICLR- and pangenome-based approaches, while approaching the performance of long-read methods.

Can Luo, Y. Liu, Han Liu et al. · Bioinformatics Advances · 0 citations

Open access Jul 2026

CNVeil resolves haplotype-specific copy number and uncovers subclonal architecture hidden from total copy number profiling in single-cell cancer genomes

CNVeil provides a scalable framework for studying tumor evolution and functional genomic heterogeneity at single-cell resolution and consistently outperformed existing tools in segmentation accuracy, ploidy inference, subclone identification, and allele-specific copy number estimation.

Weiman Yuan, Can Luo, Yunfei Hu et al. · bioRxiv · 0 citations