Author

Can-Jie Ma

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Open access Sep 2026

A core transcriptional regulatory circuitry controls super-enhancer-driven activation of LGR5 in colorectal cancer

The core transcriptional regulatory program governed by a small set of master transcription factors is pivotal for establishing context-specific cellular features. Here, we report the roles of master factor MYC in actively regulating cancer-type specific super-enhancer activity and orchestrating a super-enhancer-depend...

Min Ye, Shi-Lan Wang, Yong-Heng Chen et al. · Nature Communications · 0 citations

Open access Aug 2026

CK2α restriction of STING accumulation underlies systemic aging

This work identifies lamin A/C (LMNA) as a critical NE scaffold that orchestrates STING regulation by recruiting both STING and Casein Kinase 2 (CK2α), and establishes the LMNA-CK2-STING axis as a key biochemical mechanism that suppresses innate immune activation at the NE.

Jie Zhang, Mei-Ling Jin, Dan Rao et al. · Nature Communications · 0 citations