Open access
Sep 2026
Beyond enrichment: pharmacogenetic heterogeneity in treatment-resistant depression.
The results indicate that TRD does not represent a single, unified PGx-predicted 'poor pharmacological responder' phenotype but instead reflects a biologically heterogeneous collection of distinct PGx profiles, and actionable PGx phenotypes are neither enriched in TRD nor associated with greater TRD severity.
B. Roberts, A. Miljevic, Lauren A. Hennessy et al.
· Pharmacogenetics & Genomics · 0 citations