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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Caillan C. McAuliffe

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Open access Sep 2026

Transcription pause and elongation regulators mediate somatic hypermutation

Somatic hypermutation (SHM) creates point mutations in immunoglobulin (Ig) gene variable (V) regions in activated B cells to support antibody affinity maturation1. SHM is initiated by activation induced deaminase (AID), a cytosine deaminase whose single-stranded DNA (ssDNA) substrate is thought to arise during RNA Poly...

Li-Zhen Wu, A. D. Yadavalli, Caillan C. McAuliffe et al. · 1 citation

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