Cai-Yun Zhu

Acute sepsis seeds long-lived brain-resident macrophages that drive microglia-dependent chronic neuroinflammation through PTN signaling

Early-life severe infection is increasingly recognized as a cause of persistent cognitive impairment; however, the mechanisms by which peripheral immune cells drive and sustain chronic neuroinflammation remain poorly understood. Although infiltrating peripheral myeloid cells are generally considered transient populatio...