Cai-Xia Li

A Dual-Level Sparsity Bayesian Framework for Rare-Variant Association Analysis Using Integrated Nested Laplace Approximation

Background. Rare genetic variants (minor allele frequency, MAF < 1%) carry a substantial share of the unexplained heritability of complex human traits, yet set-based association tests lose power precisely in the regime in which rare variation is most informative — when only a small minority of the variants inside a gen...