Cai-Hua Yang

A single-nucleus transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespan

Brain aging is a major risk factor for cerebrovascular and neurodegenerative diseases, yet continuous cell-type changes across the human lifespan remain incompletely defined. Here, we integrate 15 prefrontal cortex (PFC) snRNA-seq datasets from 158 neurologically healthy donors (19–101 years) to construct an atlas of...