Review
Open access
Jul 2026
Metabolic engineering of Komagataella phaffii for enhanced production of heterologous proteins and small molecules: key strategies and future directions
This review provides an overview of advances in K. phaffii metabolic engineering and analyzes core optimization strategies, including metabolic flux control, metabolic dynamic control, application of system modeling, chassis cell optimization, and recombinant protein and small-molecule production.
Jiao-Yu Xin, Lu Zhao, You-Xin Meng et al.
· Applied and Environmental Mi... · 1 citation