BOS engages structural-cell circuits largely shared with RAS and fibrotic lung diseases, but along an airway-centered rather than parenchyma-centered axis, and shared structural programs may therefore be targetable across CLAD phenotypes.
Jannik Ruwisch, Hande Yilmaz, Leonard Christian et al.· bioRxiv· 0 citations
A potential involvement of vascular remodelling in CLAD pathophysiology is suggested, with changes consistent with pro-inflammatory and fibrogenic processes in CD31+ regions.
Axelle Coppens, Rahel Bodenmann, Janik Riese et al.· American Journal of Transpla...· 1 citation
Considering the multifaceted differences of RAS and idiopathic pulmonary fibrosis, a surprising general principle of an entity-spanning composition of the fibrotic niche by aberrant basaloid cells localized at the fibrotic edge, ectopic COL15A1+ pVECs and CTHRC1+ fibrotic fibroblasts is revealed.
L. Leiber, Leonard Christian, L. Neubert et al.· European Respiratory Journal· 0 citations
This study demonstrates the successful production and injection of human induced pluripotent stem cell cardiomyocyte aggregates into infarcted cynomolgus monkey hearts, resulting in substantial, structured human grafts three months after cell transplantation, and uncoupling of cardiomyocyte production from transplantat...
I. Gruh, Andreas Martens, S. Cebotari et al.· Nature Communications· 0 citations
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