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Open access Aug 2026

Phenotypic Factors and Celecoxib Efficacy in Knee OA: A Post‑hoc Pooled Analysis of Two Randomized, Double‑Blind, Placebo‑Controlled Trials

Knee osteoarthritis (OA) is a major cause of disability worldwide and disproportionately affects women and individuals with obesity. Treatment response might vary by sex and body mass index (BMI). This study assessed whether celecoxib pain reduction differs across sex (male versus female) or BMI (obese ≥ 30 kg/m2 versu...

J. Reginster, Nicholas Fuggle, E. Biesheuvel et al. · 0 citations
Review Open access Sep 2026

Improving Clinical Trial Design in Low Back Pain: Insights from Studies of Gabapentinoids.

Low back pain (LBP) is one of the leading causes of disability worldwide, affecting hundreds of millions of people globally. Scientific literature continues to highlight key issues in managing these patients, including accuracy of diagnostic terminology, identification of the specific pain mechanisms, and lack of effec...

Ralf Baron, Rainer Freynhagen, B. Morlion et al. · 0 citations

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