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Astrocytic polyamine clearance via ATP13A4 tunes extracellular spermidine to shape synapse formation during development, showing how brain extracellular levels are controlled has remained unclear.
P4‑ATPase lipid flippases establish transbilayer lipid asymmetry in eukaryotic membranes, with increasing evidence indicating a role for interacting partners in regulating flippase activity. However, assessing interactor‑dependent effects on flippase activity in mammalian cells is complicated by heterogeneous protein e...
It is revealed that injury-induced adult-born neurons survive, mature, and integrate synaptically into preexisting circuits, and that this coincides with the recovery of learned avoidance behavior by two months postinjury.
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